Miles Upshur is a freelance investigative journalist who one day receives a strange message from an anonymous source. The message tells of inhumane experiments performed on inmates in Mount Massive Asylum, a secluded psychiatric hospital in Lake County, Colorado run by the corrupt Murkoff Corporation.Based on the tip off, Miles decides to travel to Mount Massive Asylum to investigate.

As Miles arrives at the asylum and begins his investigation, he is horrified to find mutilated corpses of the staff, including a dying SWAT officer who warns him to get out while he still can. As Miles walks through the asylum, he finds the asylum's patients, freely roaming the grounds and hostile towards him, in particular a hulking sadist named Chris Walker. Without any traditional weapons, players will control Miles and navigate the asylum's ransacked environment with parkour: jumping over low obstacles, crawling, and sliding through narrow gaps. With dark creatures lurking in every corner, will Miles be able to escape the asylum and survive?