Surviving almost certain death, Commander Shepard finds himself indebted to Cerberus, a human extremist organisation trying to find out the source behind the destruction of numerous fringe human colonies by a race of aliens known as the Collectors. Shepard is now tasked with organising a team that would follow him into unknown depths of space to bring an end to this menace.

With new environments in the very depths of space, Mass Effect 2 pits players into a dangerous world where allies and enemies are hard to tell apart. Navigating both battlefields and personal relations, Commander Shepard finds himself burdened with responsibilities never expected before.