After South American nations form the Federation and conquer part of the United States, the war has been drawn back to a stalemate. A troupe of elite combatants known as Ghosts work behind enemy lines to dislodge the Federation. Undertaking secret, deadly missions, Ghosts fight in the dark - unseen and lethal, as they fight to liberate their homeland and drive back the Federation.

Ghosts is the next-generation Call of Duty game from the creators of the Modern Warfare series, taking players into a line of destroyed cities with Riley the German Shepherd as they fight in an elite force against a seemingly insurmountable enemy.